What's new in healthy aging, explained in plain English: the studies, the treatments people are trying, and what experts say about them.
Read every morning from PubMed · ClinicalTrials.gov · bioRxiv · medRxiv · FDA
Extends lifespan in mice. Human studies so far are small.
Pick what matters to you. Each guide shows what people try, how far the research on each has got, and the products and tests that go with it.
Look youngerFace and skin · Hair · Body · Clinic treatments14 options compared →
Stay strong and mobileMuscle · Bones and joints · Balance and mobility7 options compared →
Protect your brain and memoryMemory and focus · Mood · Sleep9 options compared →
Heart and blood pressureBlood pressure · Cholesterol · Blood sugar19 options compared →
Healthy weightAppetite and weight · Metabolism7 options compared →
EnergyDaily energy · Recovery2 options compared →Popular treatments and supplements, placed by how far testing in people has gone. A stage shows how much research there is, not whether something will work for you. Select one for details.
A molecule the body uses to make NAD+, which cells need to turn food into energy.
Stage 2 because there are 9 published trials and 55 registered trials in people, but no large ones yet.
Stages are worked out automatically from PubMed, ClinicalTrials.gov and FDA records every morning. They show how far research has got, not how well something works. Companies cannot pay to change them. How stages work · All treatments
Stages are worked out automatically from the research records every morning. They show how far research has got, not how well something works. How stages work
These tests estimate how old your body seems, or how fast it is aging, from a finger prick, a cheek swab or a blood draw. People use them to see where they are starting from and to track changes over time.
Results are estimates. The science behind them is still settling, and two tests can give the same person different numbers.
Chemical tags on your DNA shift as you age. A clock reads thousands of them and estimates a biological age.
What the research shows so farStrong for large groups of people. Less certain for one person tracked over time.
6 papers on TruAge in PubMed →Sugar chains attached to your antibodies change with age and inflammation. A newer approach with a smaller research base.
What the research shows so farPromising research, with fewer independent studies so far.
6 papers on GlycanAge in PubMed →Standard lab measures like blood sugar, cholesterol and inflammation, sometimes combined into an age score.
What the research shows so farEach marker is well studied. Combined age scores are less so.
The supplements people ask about most: how far the research has got, what studies found, and what makers sell. Forms and doses are copied from each label; we don't rank products.
Taken forA molecule the body uses to make NAD+, which cells need to turn food into energy.
A review of studies found that effects of NMN and a related compound on health outcomes were mixed and often null.
Taken forA compound gut bacteria make from foods such as pomegranates, berries and walnuts. It is studied for how cells clear out worn-out energy parts.
A review of studies found urolithin A raised some mitochondrial genes, signs of autophagy, and fatty acid burning. Mitochondria are the cell's energy makers.
Taken forNR (nicotinamide riboside) is a compound that can raise levels of NAD+, a molecule in the body that declines with age.
A review of studies found that oral NR raised NAD-related substances in blood or cells in humans.
Taken forFats found in oily fish such as salmon and sardines, and in some plant and algae oils.
A 2020 review of 23 studies found that EPA and DHA reduce triglycerides, a type of blood fat, by about 15 percent.
Taken forWithout enough vitamin D, bones can become thin, brittle, or misshapen.
In trials, vitamin D and calcium may have raised bone density in some postmenopausal women and older men, but effects on falls and fractures are unclear.
The new research most useful to everyday readers: studies in people, popular treatments, big trials and FDA news.
This review looks at small molecules carried in body fluids that may help exercise affect the aging brain.
7 ideas scientists are testing, each shown by the research stages its treatments have reached so far, from studies in animals to approval or a major guideline.
Each lit step shows how many of the idea's treatments have reached that stage. A stage is for a treatment's main use on this site: stage 4 means approved or recommended for something, not for reversing aging. New studies are sorted into these ideas automatically every morning.
Every aging-related trial that is recruiting, explained in plain words: what is tested, who can join, and where.
Everything we read each morning, with the original papers, trial records and the exact searches behind every number.
Services, prices and places are copied from each clinic's own site, word for word, and dated. We don't rate clinics, and a paid listing never changes what we show.
61 clinics in 16 countries, with what each says it offers and charges.
First Visit “30-minutes. We'll dig into your symptoms, health history, and goals, then build a care plan tailored to you.”Clinic site ↗
Single injection or aesthetic-only treatment “This life-improving therapy involves a significant personal investment , one that reflects 100M+ fresh, verified cells with 99% viability , processed in-house with complete chain-of-custody standards.”Clinic site ↗
Advanced Detox “Our signature Chenot programme aims to induce a deep purification and detoxification of the body to eliminate toxins, increase vitality, reset energy levels and rebalance its physiology.”Clinic site ↗
The popular books on aging, and how far the research on what they discuss has got.
The week's most useful new research on aging, explained for everyday readers. Sent Sundays at 7 AM ET.
One email a week · Free · Unsubscribe anytime
